A systematic review and activation likelihood estimation meta-Analysis of the central innervation of the lower urinary tract: Pelvic floor motor control and micturition

Purpose Functional neuroimaging is a powerful and versatile tool to investigate central lower urinary tract (LUT) control. Despite the increasing body of literature there is a lack of comprehensive overviews on LUT control. Thus, we aimed to execute a coordinate based meta-Analysis of all PET and fMRI evidence on descending central LUT control, i.e. pelvic floor muscle contraction (PFMC) and micturition. Materials and methods A systematic literature search of all relevant libraries was performed in August 2020. Coordinates of activity were extracted from eligible studies to perform an activation likelihood estimation (ALE) using a threshold of uncorrected p 0.001. Results 20 of 6858 identified studies, published between 1997 and 2020, were included. Twelve studies investigated PFMC (1xPET, 11xfMRI) and eight micturition (3xPET, 5xfMRI). The PFMC ALE analysis (n = 181, 133 foci) showed clusters in the primary motor cortex, supplementary motor cortex, cingulate gyrus, frontal gyrus, thalamus, supramarginal gyrus, and cerebellum. The micturition ALE analysis (n = 107, 98 foci) showed active clusters in the dorsal pons, including the pontine micturition center, the periaqueductal gray, cingulate gyrus, frontal gyrus, insula and ventral pons. Overlap of PFMC and micturition was found in the cingulate gyrus and thalamus. Conclusions For the first time the involved core brain areas of LUT motor control were determined using ALE. Furthermore, the involved brain areas for PFMC and micturition are partially distinct. Further neuroimaging studies are required to extend this ALE analysis and determine the differences between a healthy and a dysfunctional LUT. This requires standardization of protocols and task-execution

State of the Art and Potentials of Additive Manufactured Earth (AME)

Additive production techniques such as 3D printing and robotics enable new production methods and possible uses for earth, as one of the most ancient building materials in the building industry. This study examines the potential of different building elements and components and their possible combinations made of or containing earthen building products. In addition to the 3D printing of lightweight, highly insulating external and heavy internal wall elements and load-bearing rammed earth walls for use as inner and outside walls are compared. Furthermore, the activation of the walls with water-based heating and cooling elements is taken into consideration. In particular, the sensitivity of earth to humidity and water has a positive effect on all life cycle phases from production through operation as a low-tech building to the end of use, i.e. the reuse as well as the possible return to natural cycles. The focus of the study is to assess the building material earth in light of modern production methodologies, the impact on indoor comfort and indoor air quality as well its life cycle assessment